Morphine metabolism

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Actual: Morphine is 35% protein bound, the metabolite morphine-3-glucuronide is 10% protein bound, and morphine-6-glucuronide is 15% protein bound. 4. Metabolism. Morphine is 90% metabolized by glucuronidation by UGT2B7 and sulfation at positions 3 and 6. 4 Morphine can also be metabolized to codeine, normorphine, and morphine ethereal sulfate. 6
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Morphine is 35% protein bound, the metabolite morphine-3-glucuronide is 10% protein bound, and morphine-6-glucuronide is 15% protein bound. 4. Metabolism. Morphine is 90% metabolized by glucuronidation by UGT2B7 and sulfation at positions 3 and 6. 4 Morphine can also be metabolized to codeine, normorphine, and morphine ethereal sulfate. 6

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Morphine is 35% protein bound, the metabolite morphine-3-glucuronide is 10% protein bound, and morphine-6-glucuronide is 15% protein bound. 4. Metabolism. Morphine is 90% metabolized by glucuronidation by UGT2B7 and sulfation at positions 3 and 6. 4 Morphine can also be metabolized to codeine, normorphine, and morphine ethereal sulfate. 6

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Morphine is 35% protein bound, the metabolite morphine-3-glucuronide is 10% protein bound, and morphine-6-glucuronide is 15% protein bound. 4. Metabolism. Morphine is 90% metabolized by glucuronidation by UGT2B7 and sulfation at positions 3 and 6. 4 Morphine can also be metabolized to codeine, normorphine, and morphine ethereal sulfate. 6

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Morphine is then further metabolized to morphine-3-glucuronide and morphine-6-glucuronide before excretion (primarily via the kidneys). However, prior to its metabolism to morphine and subsequent glucuronidation, heroin is rapidly metabolized to 6-MAM.

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morphine and morphine glucuronides after oral morphine. The morphine: comparative metabolism and effect of morphine and phenobarbital treatment.

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codeine is metabolized to morphine and small quantities to hydrocodone, these drugs may be found in the urine. Also, morphine may metabolize to produce a

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Morphine is 35% protein bound, the metabolite morphine-3-glucuronide is 10% protein bound, and morphine-6-glucuronide is 15% protein bound. 4. Metabolism. Morphine is 90% metabolized by glucuronidation by UGT2B7 and sulfation at positions 3 and 6. 4 Morphine can also be metabolized to codeine, normorphine, and morphine ethereal sulfate. 6

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Expected limits of morphine and hydromorphone (as a result of morphine metabolism) concentrations in the urine were established. Part II of this study used the metabolic ratio (hydromorphone-morphine) to determine the inter-patient and intra-patient variability in morphine metabolism to hydromorphone. Metabolic ratio values varied over a large

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by L Ladebo 2024 Cited by 4Polymorphisms affecting drug metabolism Morphine is primarily metabolized in the liver by UGT2B7 to morphine-3-glucuronide (90%) and morphine-6-glucuronide (

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