Allopurinol half life
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Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.
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Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.
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Half-life. The plasma half-life of allopurinol is 1-2 hours, due to its rapid renal clearance Label. Clearance. Since allopurinol and its metabolites are mainly eliminated by the kidney, accumulation of this drug can occur in patients with renal dysfunction or failure, and the dose of allopurinol should, therefore, be reduced.
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Brand Names ; Aloprim, Zyloprim. N/A. Other allopurinol brands include: Aloprim ; Half Life The half-life of a drug is the time taken for the plasma concentration
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Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.
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Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.
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Allopurinol ; Metabolism, hepatic (80% oxypurinol, 10% allopurinol ribosides) ; Half life, 2 hours (oxypurinol hours) ; Excretion ? ; Therapeutic
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Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 allopurinol and allopurinol riboside enter the pu-.
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Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.
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