Concurrent use of the anti-protozoal pyrimethamine may increase methotrexate may decrease the clearance of methotrexate causing elevated methotrexate.
Pyrimethamine is predicted to increase the risk of adverse effects when given with Methotrexate. Manufacturer makes no recommendation.
Methotrexate is a medication that treats arthritis, psoriasis and other inflammatory conditions Pyrimethamine; Retinoids such as isotretinoin and tretinoin
Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine.
In addition, we evaluated the combination of pyrimethamine and methotrexate on cytokine-stimulated STAT3 activity. The combination showed no additional inhibitory effect compared with the single agents (Fig. 4 C), suggesting that both pyrimethamine and methotrexate reduce STAT3 transcriptional activity via the same molecular target, namely DHFR
Pyrimethamine, Artemisinin Methotrexate, Dactinomycin, Doxorubicin Hydrochloride, Vinblastine Sulphate, Cisplatin, Dromostanolone Propionate.
In addition, we evaluated the combination of pyrimethamine and methotrexate on cytokine-stimulated STAT3 activity. The combination showed no additional inhibitory effect compared with the single agents (Fig. 4C), suggesting that both pyrimethamine and methotrexate reduce STAT3 transcriptional activity via the same molecular target, namely DHFR
Increase in haematologic methotrexate toxicity (increase in free methotrexate plasma concentration Both pyrimethamine and sulfadoxine are excreted mostly via
methotrexate. Folic Acid may reduce the anti-parasitic effect of pyrimethamine and also increase the risk of pyrimethamine induced bone marrow suppression
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