Citrate lock

☑️@citrate_lock · 6143 subscribers · Content 18+ 🔞
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Actual: Taurolidine, a broad-spectrum, antimicrobial, nontoxic agent that reduces the development of biofilm is a nonantibiotic lock alternative that does not cause bacterial resistance and has no adverse effects, even if it leaks into circulation. 23,24 Studies with taurolidine–citrate locks (a combination of taurolidine with 4% citrate) in tunneled
4.3 rating 2025-04-24
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These antimicrobial lock solutions could be divided into antibiotic (e.g. vancomycin) and non‐antibiotic (e.g. citrate) solutions. Antimicrobial lock solutions should fill the catheter lumen and then be locked in the catheter during in‐between HD sessions with or without heparin.

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An antimicrobial-containing citrate lock is better than a heparin lock in the prevention of catheter-related infection, while citrate alone fails to show a similar advantage. BACKGROUND Citrate solution has been suggested as an effective and safe catheter lock in hemodialysis. However, whether a citrate lock is superior to a heparin lock in preventing catheter-related

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Citrate solution has been suggested as an effective and safe catheter lock in hemodialysis. However, whether a citrate lock is superior to a heparin lock in preventing catheter-related infections and maintaining catheter patency is inconclusive.

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Catheter lock solution, anti-clotting and antimicrobial is one of the innovations from Dirinco. Citra-Lock is recommended in the European Renal Best Practice Guidelines (ERBP) and the American Society of Diagnostic and Interventional Nephrology (ASDIN). Citra locks have been extensively studied. Citra-Lock is effective in maintaining catheter patency. The Citrate lock is based on tri-sodium

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The prevention of CRB with citrate-alone lock solutions has been controversial. Of four studies on CRB, only one RCT identified a difference between citrate and heparin lock solutions (RR, 0.26; 95% CI, 0.13-0.55) . Thus, further high-quality randomized trials are needed to clarify the benefits of citrate alone for prevention of CRB.

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Antimicrobial-containing citrate lock solutions are more effective than heparin lock solutions for the prevention of catheter-related bloodstream infections (CRBSIs), say researchers.

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More recently, Moore and colleagues compared heparin with a gentamicin/trisodium citrate catheter lock solution in a prospective multicenter, observational cohort of patients receiving chronic dialysis dialyzing through a tunneled catheter and found that the gentamicin/citrate lock was associated with reductions in both catheter-related

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One newly developed locking solution has reduced the ethanol concentration in the locking solution to 20% in combination with 0.01% glyceryl trinitrate and 7% citrate. This lock showed promising results in eradicating biofilm in an in vitro test .

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Whether citrate lock is more effective than saline solution or heparin lock in intensive care unit (ICU) settings and whether it is associated with a lower incidence of CRBSI remain unclear . We hypothesized that the risk of dialysis catheter infection would be lower with the use of sodium citrate locks in the ICU. This study aimed to compare

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