Bivalirudin half life

Distribution. Bivalirudin does not bind to plasma proteins (other than thrombin) or to red blood cells. Elimination. Bivalirudin has a half-life of 25 minutes

Bivalirudin is a small peptide that inhibits thrombin reversibly. Bivalirudin is cleared by proteases including thrombin with approximately 80% elimination by enzymatic cleavage and the other 20% is renally eliminated. The elimination half-life of bivalirudin is 20 30 min in the presence of normal renal function.

Bivalirudin is a reversible direct thrombin inhibitor Elimination is predominantly by proteolytic enzyme inactivation (80%) whilst renal clearance accounts for approximately 20% of its elimination The initial clearance half-life of bivalirudin is 25 minutes. Clearance is not

The elimination half-life of bivalirudin is 20 to 30 min in the presence of normal renal function while with renal dysfunction, half-life can be prolonged

half-life of 25 minutes and only 20% is excreted through the kidneys (12) d) Bivalirudin has a half-life of approximately 2 hours. 3. Compared to

Bivalirudin reversibly inhibits thrombin, with an elimination half-life of min, which can be variably prolonged in renal failure; it is widely used as a

Half-life of free bivalirudin and bivalirudin-carrying micelles (MB). (A,B) Free FAM-bivalirudin and FAM-MB were intravenously injected into

Bivalirudin does not bind to plasma proteins (except thrombin) or to red blood cells. Elimination. Bivalirudin has a half-life of 25 minutes in PTCA patients with normal renal function. The total body clearance of bivalirudin in PTCA patients with normal renal function is 3.4 mL/min/kg. Metabolism. Bivalirudin is metabolized by proteolytic

There is no reversal agent for Bivalirudin. Elimination half-life: 25mins.