Allopurinol half life

Allopurinol may also increase the activity or half-life Co-administration of the following drugs may make allopurinol less active or decrease its half-life:.

allopurinol has a plasma half-life of about 1 to 2 hours. Oxipurinol allopurinol tablets prolong the half-life of the anticoagulant, dicumarol. The

Allopurinol is metabolized in the liver and has a 1 3 hour half-life, while oxypurinol is excreted in the urine and has a 12 17 hour half-life. Therefore, allopurinol can be dosed once daily, with lower dosage requirements in patients with renal insufficiency, as the half-life of oxypurinol increases as the creatinine clearance decreases.

allopurinol; maintain TDD of allopurinol when initiating lesinurad/allopurinol Reported that allopurinol prolongs the half-life of dicumarol, a coumarin

neuropathy, neutropenia, and vacuolar my- opathy can develop in patients allopurinol. Allopurinol is metabolized in the liver and has a half-life

Allopurinol ; Metabolism, hepatic (80% oxypurinol, 10% allopurinol ribosides) ; Half life, 2 hours (oxypurinol hours) ; Excretion ? ; Therapeutic

Allopurinol: Mechanism of Action and Safety. Allopurinol has an oral bioavailability of approximately 80% . It has a half-life of one hour, however, the half-life of the active metabolite oxypurinol is much longer at 23 h. Allopurinol is predominately excreted by the kidneys as its active metabolite oxypurinol . Xanthine oxidoreductase

Allopurinol prolongs half-life of oral anticoagulants; allopurinol increases substitute for professional advice, diagnosis or treatment. Lybrate is

The plasma half-life of allopurinol is 1-2 hours, due to its rapid renal clearance Label. The plasma half-life of allopurinol is 1-2 hours, due to its rapid