Lexapro interacts with many different drugs, but no studies to date mention any drug interactions between Lexapro and melatonin or melatonin analogs such as ramelteon or agomelatine. A 2024 review published in the journal Natural Medicine Journal, examined melatonin's documented drug interactions.
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gabapentin hydroxyzine hydroxyzine Lamictal (lamotrigine) Lamictal (lamotrigine) Lexapro (escitalopram) Lexapro (escitalopram) melatonin
However, certain mechanisms of action suggest potential interactions between the two. Melatonin and Lexapro may both impact serotonin levels in the brain. While melatonin primarily influences the production and release of serotonin, Lexapro acts on serotonin reuptake. Therefore, combining melatonin and Lexapro could potentially lead to
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What is Lexapro? Lexapro has active ingredients of escitalopram oxalate. It is often used in depression. eHealthMe is studying from 91,407 Lexapro users for its effectiveness, alternative drugs and more. What is Melatonin? Melatonin has active ingredients of melatonin. It is often used in insomnia.
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I grant that the effect is real, as many women on Lexapro have found, but its administration has to be subtle.