QTc-Prolonging Drugs: Pharmacokinetic and pharmacodynamic studies of fluoxetine combined with other medicinal products that prolong the QT
CITALOPRAM ESCITALOPRAM – dose-dependent QT interval prolongation. Fluoxetine. A prolonged QT interval is not a listed adverse effect of
fluoxetine hydrochloride, equivalent to 10 mg of fluoxetine. Nonmedicinal QT prolongation. QT prolongation is a serious life-threatening condition
Fluoxetine should be used with caution in patients with congenital long QT syndrome; a previous history of QT prolongation; a family history of long QT syndrome
Do not use fluoxetine with pimozide due to risk of QT interval prolongation and drug interaction. Do not use fluoxetine with thioridazine due to risk of QT
may cause QT interval prolongation; however QTc Prolongation Associated with Combination Therapy of Levofloxacin, Imipramine, and Fluoxetine.
QT Prolongation: QT prolongation and ventricular arrhythmia including Torsades de Pointes have been reported with fluoxetine use. Use with caution in conditions that predispose to arrhythmias or increase fluoxetine exposure. Use cautiously in patients with risk factors for QT prolongation (4.2, 5.11, 7.6, 7.7, 10)
Fluoxetine prolongs the QT interval; the prescribing information for fluoxetine recommends avoiding concurrent use of other drugs that may prolong the QT interval; risk may be increased with higher doses and/or when associated with hypokalemia; drugs that prolong the QTc interval may potentiate the effects of betanists on the
Heart rhythm: Fluoxetine can cause changes to the normal rhythm of the heart, including an irregular heartbeat called QT prolongation. QT prolongation is a
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