Action of allopurinol
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Allopurinol (Zyloprim, Aloprim) What is allopurinol, and how does it work (mechanism of action)? What are the uses for allopurinol? What are the side effects
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Mechanism of Action of Allopurinol and Colchicine Used in Gout
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Both allopurinol and oxypurinol inhibit the action of this enzyme. Allopurinol and oxypurinol are also converted by the purine salvage pathway to their respective ribonucleotides. The effect of these ribonucleotides related to the hypouricemic action of allopurinol in humans is not fully elucidated to this date.
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Mechanism of Action: Allopurinol blocks the production of uric acid by inhibiting the action of xanthine oxidase. Indications: Allopurinol is used for the prevention of gouty arthritis and for the treatment of secondary hyperuricemia. Nursing Considerations: Allopurinol is safe for all ages.
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Both allopurinol and oxypurinol inhibit the action of this enzyme. Allopurinol and oxypurinol are also converted by the purine salvage pathway to their respective ribonucleotides. The effect of these ribonucleotides related to the hypouricemic action of allopurinol in humans is not fully elucidated to this date.
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