Hyaluronidase for extravasation

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Actual: ▻ Amiodarone. ▻ Doxycycline BNF indications and dose: Hyaluronidase for treatment of extravasation by local infiltration Adult:.
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The only antidote reported to have been used for the management of nafcillin extravasation is hyaluronidase. By facilitating the diffusion of extravasated

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Management of amiodarone extravasation with intradermal hyaluronidase. Administration, Intravenous Administration, Intravenous Amiodarone Amiodarone

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Hyaluronidase Hyaluronidase is an enzyme that degrades hyaluronic acid, improving the absorption of the extravasated drugs into circulation where they can be metabolized [1]. A study with seven human patients with accidental vinca alkaloid extravasation showed no skin necrosis after local treatment with hyaluronidase [7].

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Antidote, Extravasation;; Enzyme. Dosing: Adult. Dispersion and absorption of Management of amiodarone extravasation with intradermal hyaluronidase.

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by AN Fox 2024 Cited by 14Treatment with intradermal hyaluronidase was administered approximately 6 hours after identification of the extravasation. Hyaluronidase was prepared by adding

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Management of extravasation injuries: A focused evaluation of Amiodarone. -Supportive management. -Hyaluronidase. (refractory cases). 1

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Hyaluronidase degrades glycosaminoglycans and hyaluronic acid, with subsequent increases in tissue permeability and dispersion of extravasated agent. 11, 14 Hyaluronidase has been used for extravasation by etoposide, taxanes (ie, paclitaxel, docetaxel, and cabazitaxel), and vinca alkaloids. 11 Although hyaluronidase is recognized as therapeutic

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Management of amiodarone extravasation with intradermal hyaluronidase. infiltration and extravasation injuries. Expand. 21 Citations PDF. Add to Library.

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assess and provide analgesia prior to and during hyaluronidase administration as required. Hyaluronidase administration: commence as soon as possible (ideally within 1 hour of extravasation) reconstitute hyaluronidase 1500 International Units in 2 to 5 mL (depending on size of extravasation) sterile water for injection or sodium chloride 0.9%

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