Nitroimidazole drugs

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Actual: The azomycin (2-nitroimidazole) produced by both Actinobacteria (Streptomyces eurocidicus and Nocardia mesenterica) and Proteobacteria (Pseudomonas fluorescens) was the only approved nitroimidazole based antibiotic[19]. Later, azomycin was used as key synthetic precursor for the development of many nitroimidazole based drugs.
4.3 rating 2025-04-24
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@amantadina_clor

To better understand treatment failure due to 5-nitroimidazole drug resistance, we performed a systematic literature review on mechanisms of 5-nitroimidazole resistance in T. vaginalis. An improved understanding of this resistance may inform development of novel therapeutic options outside of the 5-nitroimidazole class.

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nitroimidazole increase with decreasing length of the side : Polyelectrolyte; maleic copolymers; N-alkyl-nitroimidazoles; partition; drugs reservoirs.

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@ciprodex_otic_c

The 5-nitroimidazole is an important class of imidazole based drugs. The 5-nitroimidazoles are a well-established group of protozoal and bactericidal agents

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@amneal_hydrocod

The 5-nitroimidazoles are a group of drugs that have both antiprotozoal and antibacterial activity. Nitroimidazoles with activity against trichomonads and amebae include metronidazole, tinidazole, nimorazole, flunidazole, and ronidazole.

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@does_benzonatat

Metronidazole (1-[2-hydroxyethyl]-2-methyl-5-nitroimidazole) is a nitroimidazole drug active against anaerobic bacteria and certain parasites.

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@white_107_pill

Single-dose nitroimidazole therapies are highly effective in the treatment of trichomoniasis. Drug-resistance in T vaginalis infection is rare, despite the prevalent use of nitroimidazole drugs. Treatment failures may require a higher-dose regimen, a longer course of the agent, or the use of different nitroimidazoles.

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by Y Miyamoto 2024 Cited by 71The prototype and most commonly used drug of this class is the 5-nitroimidazole (5 JA Upcroft, et al, 5-Nitroimidazole drugs effective

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@hydroxyzine_and

Based on the therapeutic utility of metronidazole, several other 5-nitroimidazoles have been developed over the years. For example, tinidazole is a position 1 derivative of 5-nitroimidazole and is effective against giardiasis . Not all antigiardial drugs are based on the 5-nitroimidazole scaffold.

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Two nitroimidazoles (1-methyl-5-nitroimidazole and metronidazole) were included as reference drugs. The. Page 1 of 17. Page 1 of 17

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