Bactrim hyperkalemia mechanism

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Actual: The increase in creatinine associated with TMP is mild: 10% and reversible with drug discontinuation. The mechanism of Bactrim induced hyperkalemia is via Trimethoprim inhibition of the sodium channel located on the luminal surface of the principal cells, independent of aldosterone blockade.
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Medscape - Indication-specific dosing for Bactrim, Bactrim DS, Septra, Septra Treatment with recommended doses may cause hyperkalemia when trimethoprim

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Hyperkalemia can be a side effect of the antibiotic Bactrim. monitoring antibiotics pharmacist Comments.

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hyperkalemia. Risk factor associated with hyperkalemia is low BMI BACTRIM (sulfamethoxazole and trimethoprim) [Package insert].

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- Hyperkalemia. - Use in renal impairment. Page 35. Bactrim hyperkalemia. Mechanism of action. Trimethoprim (TMP). – Structural and pharmacologic similarities

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6. Bactrim: the hyperkalemia induced by Bactrim is via an ENaC inhibitory effect exerted by the trimethoprim moiety. Pentamidine induced hyperkalemia via a similar mechanism. 7. calcineurin inhibitors (e.g, cyclosporine, tacrolimus): it is postulated that these medications inhibit renal tubular responsiveness to aldosterone. 8.

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6. Bactrim: the hyperkalemia induced by Bactrim is via an ENaC inhibitory effect exerted by the trimethoprim moiety. Pentamidine induced hyperkalemia via a similar mechanism. 7. calcineurin inhibitors (e.g, cyclosporine, tacrolimus): it is postulated that these medications inhibit renal tubular responsiveness to aldosterone. 8.

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Bactrim, Spironolactone and Lisinopril. Stay Away! A Dangerous Cocktail for Hyperkalemia. Introduction: Hyperkalemia is a potentially life-threatening complication of several medications, particularly in situations of polypharmacy.

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The increase in creatinine associated with TMP is mild: 10% and reversible with drug discontinuation. The mechanism of Bactrim induced hyperkalemia is via Trimethoprim inhibition of the sodium channel located on the luminal surface of the principal cells, independent of aldosterone blockade.

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In addition to an elevated creatinine, Bactrim is also associated with hyperkalemia. The mechanism is felt to be a decreased aldosterone-

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