Drugs that increase inr

that may lead to increased INR readings and thus, increased risk of bleeding (i.e, blood is. too thin). When starting or changing these drugs, INRs should be

Medications that interact with warfarin by increasing the INR and chances of a catastrophic bleed, or by decreasing the INR and exposing patients to the risk

A mild increase in the INR is not unexpected with prednisone, but warrants particular caution if the patient requires a second drug that also affects INR for example, trimethoprim

The prevalence of supratherapeutic INR events (INR 3.0) and bleeding occurrences among the The Mean INR of the patients increased

(INR). This INR reading indicates the ability of a patient's blood to Interaction with these medicines will increase the effect of

In a moderate potentiation, the INR increased to greater than 5.0 or there was an increase in INR by greater than 1.5. Minor potentiation interactions were defined as an INR increase in which no change in warfarin dosage was required. INR increased to less than 5 and the increase of INR was less than 1.5 units in a minor potentiation.

Bleeding. Risk increased when INR 3; Exponential increase when INR 5; Avoid giving NSAIDs, sulfas, macrolidies (azithromycin ok)

significant changes in the INR and increase the propensity for bleeding or clotting are drug interactions. INR values with a need for increased warfarin doses

INR 1.8 1.9 No dosage adjustment may be necessary if the last two INRs were in range Repeat INR within 8 weeks Consider a one-time dose increase of 1 times daily maintenance dose If adjustment to maintenance dose needed, increase dose by 5-10% Repeat INR in 2 weeks INR 2.3 2.4 INR 2 3 Desired range