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We developed and validated a novel, sensitive, selective, and inexpensive high-performance liquid chromatography (HPLC) method for the determination of tadalafil in rats
Abstract. We developed and validated a novel, sensitive, selective, and inexpensive high-performance liquid chromatography (HPLC) method for the determination of tadalafil in rats plasma and to investigate the effect of grapefruit juice on the pharmacokinetics of tadalafil in rats.
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The first synthesis of tadalafil 1 from the inexpensive l-tryptophan methyl ester hydrochloride has been discussed.The title compound 1 was obtained in 42.3% overall yield
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