Glycopyrrolate for bradycardia

Atropine and glycopyrrolate are usually used in anesthesia to prevent or treat bradycardia and to minimize salivation and respiratory secretions.

Glycopyrrolate Dosage Use to counteract drug-induced or vagal reflexes associated with arrhythmias (e.g. bradycardia) Drugs may be

of intraoperative bradycardia in horses. Clinical Uses. Glycopyrrolate is used perioperatively to prevent severe bradycardia caused by surgical manipulation

Approved glycopyrrolate indications Chronic drooling Reduction of secretions (Injections) Reversal of bradycardia, vagal reflexes (Injections)

by W Ittichaikulthol 2024 Cited by 7elimination of the risk of initial bradycardia from single, small dose of glycopyrrolate. The authors found that half dose of glycopyrrolate plus atropine

Glycopyrrolate protects against the peripheral muscarinic effects (e.g, bradycardia and excessive secretions) of cholinergic agents such as

Glycopyrrolate antagonizes muscarinic symptoms (e.g, bronchorrhea, bronchospasm, bradycardia, and intestinal hypermotility) induced by cholinergic drugs such as the anticholinesterases.

bradycardia. Disadvantage of glycopyrrolate over atropine: Glycopyrrolate is less effective in increasing the heart rate. epinephrine. (back

My understanding is glycopyrrolate doesn't cross BBB so it is generally the preferred agent in the OR for mild bradycardia, especially in the elderly.