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In terms of side effects, Abilify and Vyvanse have some differences. Abilify may cause more side effects like weight gain and drowsiness, while Vyvanse may
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Other than Abilify increasing and Vyvanse decreasing appetite, the likeliest clash would be Abilify diminishing Vyvanse's action on dopamine. Which could be a good or a bad thing depending on why Vyvanse is underperforming for you. Don't drop Vyvanse unless you're told to, I'd suggest.
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