Drugs that cause neutropenia

Although it is not the most common cause of all neutropenias (ANC 1.5 10 9 neutrophils/L), drug-induced neutropenia must be considered in patients with unexplained neutropenia. Drug-induced neutropenia is also a serious concern for the development of new drugs 1 because it can be missed in clinical trials if the incidence is low; in severe

The most common drugs associated with severe neutropenia are antithyroid medications, ticlopidine, clozapine, sulfasalazine, trimethoprim-sulfamethoxazole, and dipyrone. 14 The mAb anti-CD20 (rituximab) also causes late-onset neutropenia. 15 If a potential causative agent is identifiable, drug-induced neutropenia is sometimes reversible at

Others causes of acquired neutropenia, such as primary immune mechanisms, chemotherapy, and infections, as well as congenital neutropenia in children are discussed separately. (See Immune neutropenia and Infectious causes of neutropenia and Congenital neutropenia and Overview of neutropenic fever syndromes .)

Both AIDS (acquired immunodeficiency syndrome ) and the drug Zidovudine can cause neutropenia. Drugs used to treat Neutropenia Associated with AIDS or

Diagnostic approach to the adult cancer patient with neutropenic fever; Drug-induced immune thrombocytopenia; Drug-induced thrombotic microangiopathy (DITMA) Immune neutropenia; Infectious causes of neutropenia; Overview of neutropenia in children and adolescents; Overview of neutropenic fever syndromes; Patient education: Neutropenia (The Basics)

Drugs given to treat these infections may also cause neutropenia. (See Drug-induced neutropenia and agranulocytosis .) This review will discuss the neutropenias that can occur during bacterial, viral, parasitic, or rickettsial infections. Approaches to determining the cause of unexplained neutropenia in children and adults are presented

The most common drugs associated with severe neutropenia are antithyroid medications, ticlopidine, clozapine, sulfasalazine, trimethoprim-sulfamethoxazole, and dipyrone. 14 The mAb anti-CD20 (rituximab) also causes late-onset neutropenia. 15 If a potential causative agent is identifiable, drug-induced neutropenia is sometimes reversible at

Drug-induced neutropenia and agranulocytosis will be reviewed here. Others causes of acquired neutropenia, such as primary immune mechanisms, chemotherapy, and infections, as well as congenital neutropenia in children are discussed separately.

Drug-induced neutropenia and agranulocytosis will be reviewed here. Others causes of acquired neutropenia, such as primary immune mechanisms, chemotherapy, and infections, as well as congenital neutropenia in children are discussed separately.