Acyclovir resistant hsv treatment
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General Information ; Lab Name: HSV Acyclovir Drug Resistance ; Lab Code: HSVDR ; Epic Ordering: HSV Acyclovir Drug Resistance ; Description. HSV Type 1 and HSV
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For HSV that is resistant to acyclovir or ganciclovir, cidofovir and foscarnet are potential alternative treatments. These drugs do not require phosphorylation
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Foscarnet was administered five to seven days following acyclovir in these cases for management of acyclovir-resistant HSV. Acyclovir-resistant HSV has a known and consistent prevalence of about 0.3% in immunocompetent patients [19, 20]. This delay in initiating a definitive treatment could explain the poorer outcomes observed with this treatment.
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Epic Ordering: HSV Acyclovir Drug Resistance ; Description. HSV Type 1 and HSV Type 2 Drug Resistance to Acyclovir in the Thymidine Kinase (UL23 only) gene
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the treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients. According to IQVIA, US sales of Foscarnet
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mechanism of action as acyclovir. Thus, HSV isolates resistant to acyclovir are also resistant to valacyclovir, famciclovir, and penciclovir. (See
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by A Birkmann 2024 Cited by 18Treatment Option for Acyclovir-Resistant Herpes Simplex Virus Infections acyclovir or its prodrug valacyclovir for the treatment of HSV
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Cross-resistance to other antivirals occurs in vitro in acyclovir-resistant mutants. HSV mutants which are resistant to acyclovir due to an
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acyclovir mode of action, mechanisms of resistance, prevalence of resistance, and alternative antiviral treatments for acyclovir resistant HSV infections.
Comments
Gavin explains , For instance, an antibiotic, if you take the same antibiotic every infection, your body will stop responding to it.
Antibiotics stop working because the dose is too low or the treamement is too short a time not because of frequent use. During treatment, the most resistant bacteria are the last to die so any bacteria that survive a course of treatment are now selected to build the next generation of stronger and more resistant bacteria.
The solution is exactly the opposite of Gavin's statement i.e. more antibiotic for a longer time to ensure all bacteria are killed.