The mature metacercariae can infect cattle, sheep, humans Treatment of human chronic fascioliasis with triclabendazole: drug efficacy and
Novartis originally developed triclabendazole to treat fascioliasis in domestic livestock, and subsequently developed it for human use in
EGATEN ; Generic Name. triclabendazole ; Product Ndc. ; Product Type. HUMAN PRESCRIPTION DRUG ; Route. ORAL ; Microbiology. 12.4 Microbiology Mechanism of
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Triclabendazole was previously used in the treatment of fascioliasis in livestock, but is now approved for human use. This drug is currently the only FDA-
Triclabendazole is effective at killing all stages of triclabendazole-susceptible flukes from two weeks old. Cattle may be slaughtered for human consumption
The plasma elimination half-life (t ) of triclabendazole, the sulfoxide and sulfone metabolites in humans is approximat, and 11 hours, respectively. Metabolism Based on in vitro studies, triclabendazole is primarily metabolized by CYP1A2 (approximately 64%) into its active sulfoxide metabolite and to a lesser extent by CYP2C9, CYP2C19
Comment: Updated review of Fasciola infection. Triclabendazole remains the only highly active medication to treat humans and livestock infected
Triclabendazole: 96.7%; Sulfoxide metabolite: 98.4%; Sulfone metabolite: 98.8% in human plasma. Use: Labeled Indications. Fascioliasis: Treatment of fascioliasis in patients 6 years of age. Contraindications. Hypersensitivity to triclabendazole, other benzimidazole derivatives, or to any component of the formulation. Dosage and
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