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Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature
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Dapoxetine pharmacokinetics were similar with administration of dapoxetine alone and coadministration of tadalafil or sildenafil; the three treatments demonstrated comparable plasma concentration profiles for dapoxetine. 76 Dapoxetine absorption was rapid, and was not affected by coadministration of tadalafil or sildenafil.
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Dapoxetine has no clinically relevant pharmacokinetic interactions with Tadalafil or Sildenafil, and the drug combinations (Tadalafil Dapoxetine or Sildenafil Dapoxetine) are well‑tolerated.[18]
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