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Author: Admin | 2025-04-28
0% (0%) 4% (0%) 1% (0%) Pain 4% (0%) 0% (0%) Dizziness 1% (0%) 0% (0%) 0% (0%) 4% (0%) Nausea 0% (0%) 0% (0%) 3% (2%) Increased Cough 0% (0%) 2% (0%) Rash 0% (0%) 2% (2%) 0% (0%) Abdominal Pain 0% (0%) 2% (0%) 0% (0%) Allergic Reaction 0% (0%) 0% (0%) 2% (0%) 0% (0%) Cardiovascular Disorder 0% (0%) 2% (2%) 0% (0%) 0% (0%) Chest Pain 0% (0%) 2% (0%) Diarrhea 0% (0%) 0% (0%) 2% (0%) 0% (0%) Flushing 0% (0%) 0% (0%) 2% (0%) 0% (0%) Emotional Lability 0% (0%) 2% (2%) 0% (0%) 0% (0%) Pruritus 1% (0%) 2% (2%) 0% (0%) 0% (0%) *Some individuals discontinued for multiple reasons. Other adverse reactions, each reported by fewer than 1% of exposed patients, and in many cases of uncertain relation to drug treatment, were:Cardiovascular: acute myocardial infarction, apoplexy, arrhythmias, bradycardia, edema, hypertension, hypotension, pallor, palpitations, tachycardia.Dermatologic: sweating.Gastrointestinal: anorexia, dry mouth, dyspepsia, thirst, vomiting, decreased weight.Genitourinary: prostatic disorder.Miscellaneous: amblyopia, back pain, bitter taste, muscle cramps, neck pain, paresthesia, susurrus aurium.Neurologic: anxiety, impaired concentration, depression, insomnia, nervousness, nightmares, restlessness, tremor, vertigo.Respiratory: asthma, dyspnea, sinusitis.Extremely rarely, ordinary doses of organic nitrates have caused methemoglobinemia in normal-seeming patients; for further discussion of its diagnosis and treatment see OVERDOSE. Additionally, rare reports of symptoms of angioedema have been reported.Drug Interactions for MonoketConcomitant use of monoket®with phosphodiesterase inhibitors in any form is contraindicated (see CONTRAINDICATIONS).Concomitant use of isosorbide mononitrate with riociguat, a soluble guanylate cyclase stimulator, is contraindicated (see CONTRAINDICATIONS).The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety.Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. Dose adjustments of either class of agents
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