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Author: Admin | 2025-04-28
US Pharm. 2014;39(11):54-55. Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared. Accurately weigh or measure each ingredient. In a glass or porcelain mortar, pulverize the tablets with a pestle to a fine powder. Add a few milliliters of Ora-Plus to the powder and mix to form a smooth paste. Geometrically, add the remainder of the Ora-Plus and mix well. Add the Ora-Sweet to volume and mix well. Package and label. Use: Adderall oral liquid has been used in the treatment of attention-deficit/hyperactivity disorder in patients who are unable to swallow the oral dosage form or in cases when the dosage needs to be titrated. Packaging: Package in tight, light-resistant containers. Labeling: Keep out of reach of children. Discard after ____ [time period]. Use only as directed. Shake well. Stability: A beyond-use date of 30 days may be used for this preparation.1,2 Quality Control: Quality-control assessment can include weight/volume, pH, specific gravity, active drug assay, color, rheologic properties/pourability, physical observation, and physical stability (discoloration, foreign materials, gas formation, mold growth).3 Discussion: Adderall is a single-entity amphetamine product that combines the neutral sulfate salts of dextroamphetamine and amphetamine with the dextro isomer of amphetamine saccharate and d,l-amphetamine aspartate monohydrate. It contains the d-amphetamine and l-amphetamine salts in the ratio of 3 to 1. Adderall consists of a mixture of amphetamine aspartate, amphetamine sulfate, dextroamphetamine saccharate, and dextroamphetamine sulfate. Amphetamine sulfate ((C9H13N)2.H2SO4, MW 368.49) occurs as a white, odorless, crystalline powder with a slightly bitter taste. In aqueous solution, it has an acid reaction to litmus, with a pH of 5 to 6. It is freely soluble in water and slightly soluble in alcohol.1 The regular immediate-release Adderall tablets should be used for this preparation, and they are available in strengths of 5 mg, 7.5 mg,
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