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Author: Admin | 2025-04-28
Insulin glargine and liraglutide.” In the study, either insulin glargine, liraglutide, glimepiride, and sitagliptin were administered to participants already taking metformin. “These drugs should be selected based on individual characteristics, because in fact, all of them lower the A1C (a measure of average blood sugar levels over the last three months),” Nathan said. “All the patients had a benefit.” Researchers may not have noticed the differences in the drugs at all if the study hadn’t lasted five years, he added. InjectableInsulin glargineLiraglutideOralGlimepirideSitagliptinLive Well With DiabetesWe're launching a new newsletter to help you manage your type 2 diabetes. Every week, we'll share symptom management advice, medication news, and more.Sign Up Now 2 Drugs Kept A1C Levels In Control the Longest The five-year trial, known as the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study, was large, with more than 5,000 people enrolled at 36 study centers. The patients were a fairly diverse group: Roughly 20% were Black, 19% were Latinx, and the rest were White. All participants had had type 2 diabetes for less than 10 years and had been taking metformin, but did not have strong control of their blood glucose levels, as shown by tests of A1C blood levels. Participants began the study with A1C levels of 6.8% to 8.5%. Under 7% is considered in control. Each of the four drugs—liraglutide, sitagliptin, glimepiride, or insulin glargine—was used along with metformin. Liraglutide, sitagliptin, and glimepiride help increase the body’s insulin levels when blood sugar levels are high, while
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