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Author: Admin | 2025-04-28
Of Exforge on Sitting Systolic Blood Pressure Amlodipine dosage Valsartan dosage 0 mg 160 mg 320 mg Mean Change* Placebo- subtracted Mean Change* Placebo- subtracted Mean Change* Placebo- subtracted 0 mg -11.0 - -18.1 -7.0 -18.5 -7.5 10 mg -22.2 -11.2 -26.6 -15.5 -26.9 -15.9 *Mean Change and Placebo-Subtracted Mean Change from Baseline (mmHg) at Week 8 in Sitting Systolic Blood Pressure. Mean baseline systolic BP was 156.7 mmHg. In a double-blind, active-controlled study, a total of 947 patients with mild to moderate hypertension who were not adequately controlled on valsartan 160 mg received treatments of 2 combinations of amlodipine and valsartan (10/160, 5/160 mg) or valsartan alone (160 mg). At week 8, the combination treatments were statistically significantly superior to the monotherapy component in reduction of diastolic and systolic blood pressures.Table 5: Effect of Exforge on Sitting Diastolic/Systolic Blood Pressure Treatment Group Diastolic BP Systolic BP Mean change* Treatment Difference** Mean change* Treatment Difference** Exforge 10/160 mg -11.4 -4.8 -13.9 -5.7 Exforge 5/160 mg -9.6 -3.1 -12.0 -3.9 Valsartan 160 mg -6.6 - -8.2 - *Mean Change from Baseline at Week 8 in Sitting Diastolic/Systolic Blood Pressure. Mean baseline BP was 149.5/96.5 (systolic/diastolic) mmHg. **Treatment Difference = difference in mean BP reduction between Exforge and the control group (Valsartan 160 mg). In a double-blind, active-controlled study, a total of 944 patients with mild to moderate hypertension who were not adequately controlled on amlodipine 10 mg received a combination of amlodipine and valsartan (10/160 mg) or amlodipine alone (10 mg).
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