Comment
Author: Admin | 2025-04-28
Brand name: CozaarDrug class: Angiotensin II Receptor Antagonists IntroductionUsesDosageWarningsInteractionsStabilityFAQ WarningMay cause fetal toxicity.When pregnancy is detected, discontinue as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.IntroductionAngiotensin II receptor type 1 (AT1) antagonist (i.e., angiotensin II receptor blocker, ARB).Uses for Losartan PotassiumHypertensionManagement of hypertension (alone or in combination with other classes of antihypertensive agents, including diuretics). Monotherapy used to treat hypertension in adults and pediatric patients ≥6 years of age. Angiotensin II receptor antagonists are recommended as one of several preferred agents for the initial management of hypertension according to current evidence-based hypertension guidelines. While there may be individual differences with respect to recommendations for initial drug selection and use in specific patient populations, current evidence indicates that these antihypertensive drug classes all generally produce comparable effects on overall mortality and cardiovascular, cerebrovascular, and renal outcomes.Stroke Reduction in Left Ventricular HypertrophyReduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy. Evidence suggests that the benefit associated with losartan-based antihypertensive therapy does not apply to Black patients. Preliminary evidence suggests that aspirin therapy at baseline in patients receiving losartan may reduce the risk of combined cardiovascular death, stroke, and acute MI compared with aspirin therapy at baseline in patients receiving atenolol.Diabetic NephropathyManagement of diabetic nephropathy manifested by elevated Scr and proteinuria (urinary albumin to creatinine ratio ≥300 mg/g) in patients with type 2 diabetes mellitus and hypertension. Recommended option in patients with diabetes mellitus, hypertension, and moderately to severely elevated albuminuria (i.e., urine to creatinine ratio >30 mg/g). May also be considered in patients with diabetes and albuminuria who are normotensive† [off-label] .Angiotensin II receptor antagonists have been used in the management of nondiabetic CKD with moderately or severely increased albuminuria† [off-label] to prevent progression of
Add Comment