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Author: Admin | 2025-04-28
Aspiration while unconscious.Ketamine - Both substances cause ataxia and bring a very high risk of vomiting and unconsciousness. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.MXE - There is a high risk of memory loss, vomiting and severe ataxia from this combination.Opioids - Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likelyTramadol - Heavy CNS depressants, risk of seizures. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place affected patients in the recovery position to prevent vomit aspiration from excess. Memory blackouts are likely.Non-psychoactive medicine interactions:ALDH2 inhibitors - A number of drugs are "disulfiram-like": they inhibit ALDH2, which breaks down the acetaldehyde, a toxic intermediate in the breakdown of alcohol. The result is a highly unpleasant and physically dangerous reaction on the consumption of alcohol, with symptoms such as vomiting, nausea, and shortness of breath.[108][109][110] Disulfiram, a drug of this class, has intentionally been used as an aversive aid for discontinuing alcohol. Other drugs with a similar activity are:[111]Disulfiram-like antibiotics: The list of antibiotics with a disulfiram-like action has been historically overinflated. Antibiotics with evidence of having this activity include cefamandole, cefmetazole, cefoperazone, cefotetan, and ceftriaxone. The unifying property is the inclusion of either a MTT or MTDT sidechain.[111] Latamoxef (moxalactam) has the same sidechain and should also be avoided. This side chain may also inhibit the body's vitamin K system independently of alcohol.[112]Acetaldehyde is not only acutely toxic, but also carcinogenic in humans. Alcoholics with a genetic
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