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Author: Admin | 2025-04-28
With caution in anesthesia or surgery (myocardial depression), bronchospastic disease, cerebrovascular insufficiency, diabetes mellitus, hyperthyroidism or thyrotoxicosis, liver disease, renal impairment, peripheral vascular disease, compromised left ventricular function, advanced age, heart failure. May mask the effects of hyperthyroidism. Risk of hypoglycemia and bradycardia in neonates born to mothers who receive the drug at parturition or while breastfeeding, especially in premature infants and those with renal impairment. Use with caution in patients taking calcium-channel blockers or cardiac glycosides or using inhaled anesthetics. Avoid abrupt withdrawal; sudden discontinuance can exacerbate angina and lead to MI. Increased risk of stroke after surgery. In patients receiving clonidine, atenolol should be discontinued several days before the withdrawal of clonidine. May cause or exacerbate CNS depression (use with caution in patients with psychiatric illness). Use in pheochromocytoma (alpha blockade required before use of beta-blocker). Consider preexisting conditions such as sick sinus syndrome before initiating therapy. May potentiate hypoglycemia and may mask its signs and symptoms in patients with diabetes mellitus; use caution. Monitor for worsening of heart failure symptoms in patients with compensated heart failure. Use caution in patients with myasthenia gravis; may precipitate or aggravate symptoms of arterial insufficiency in patients with Raynaud's disease and peripheral vascular disease; use caution and monitor for progression of arterial obstruction. Avoid beta-blockers without alpha1-adrenergic receptor blocking activity in patients with Prinzmetal variant angina; unopposed alpha1-adrenergic receptors mediate coronary vasoconstriction and can worsen anginal symptoms. Exacerbation or induction of psoriasis reported with beta-blocker use; cause and effect not established.Pregnancy and Lactation Use atenolol during pregnancy only in LIFE-THREATENING emergencies when no safer drug is available. There is positive evidence of human fetal risk. Atenolol enters breast milk; neonates born to mothers who are receiving atenolol at parturition or breastfeeding may be at risk for hypoglycemia and bradycardia; use with caution if breastfeeding. From References SOURCE:Medscape. Atenolol.https://reference.medscape.com/drug/tenormin-atenolol-342356
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