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Author: Admin | 2025-04-28
Addiction concluded that gabapentin and pregabalin increase the risk of overdose among people who use heroin. The authors of the study think the drugs affect a person’s tolerance and cause an extra effect on slowed breathing.Diphenhydramine (Benadryl)In general, doctors try to avoid prescribing opioids alongside other sedatives. Diphenhydramine, the active ingredient in the antihistamine Benadryl, is used to relieve symptoms of allergies and hay fever. Its side effects include drowsiness and dizziness.A 1985 study of rats concluded diphenhydramine potentiated the pain-relieving effects of the opiate morphine. More recent studies found antihistamines can relieve pain. But experts don’t clearly understand how antihistamines and opioids affect one another.People who want to potentiate opioids often try Benadryl because of its availability. But it’s unclear how effective the antihistamine is at increasing the effects of opioids. The drugs may have a synergistic effect on sedation, meaning the sedative effects of both drugs together are greater than the effects of either drug separately. But more evidence is needed to know for sure, according to a 2010 review published in The American Journal on Addictions.People use several substances to potentiate the effects of opiates, and many of these substances interact with the drugs to cause dangerous side effects. You should never attempt to increase or potentiate the effects of an opiate or opioid without consulting a doctor. Author Senior Content Writer, DrugRehab.com Chris Elkins worked as a journalist for three years and was published by multiple newspapers and online publications. Since 2015, he’s written about health-related
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