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Author: Admin | 2025-04-28
Accidental injury. You shouldn’t drive a car or use machinery when you begin an opioid prescription or change your dosage. You should never perform these activities if you’re trying to potentiate the effects of an opioid.Grapefruit JuiceGrapefruit juice is one of the most well-known legal substances people use to potentiate hydrocodone, oxycodone and other opioids. The juice changes the way the body metabolizes, or breaks down, certain opioids.Drinking grapefruit juice while taking opioids can make a larger portion of the drug reach the brain. It can also make opioids stay in your system for longer periods of time.A 2010 study published in the journal Basic & Clinical Pharmacology & Toxicology investigated the effects of mixing grapefruit juice and oxycodone. The researchers concluded that grapefruit juice “increases the concentrations and effects of oxycodone.”Hydromorphone, morphine and oxymorphone are not metabolized in the same way, according to a 2009 review published in Pain Medicine. Grapefruit juice is unlikely to have a significant effect on metabolism of those drugs.GabapentinGabapentin (Neurontin) and pregabalin (Lyrica) are prescription drugs used to treat nerve pain and other conditions. Some people use the nerve-pain drugs to potentiate the effects of opioids.A 2014 study in Europe surveyed people attending six different rehabs. Twenty-two percent of patients reported misusing gabapentin or pregabalin, and 38 percent of those patients said they used the drugs to potentiate the effects of methadone.Experts aren’t sure of the exact manner in which opioids interact with gabapentin and pregabalin. But a 2017 study published in the journal
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