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Author: Admin | 2025-04-28
Drugs can interfere with zolpidem pharmacokinetics and cause adverse effects like increased CNS depressant effects, excess sedation, respiratory depression, complex sleep-related behaviors, and lack of full mental alertness. Some drug interactions can make zolpidem less effective. Other drugs can increase plasma concentrations of zolpidem and raise the risk of serious adverse reactions. Some of the medications you should avoid when taking zolpidem include:Opioid drugs like hydrocodone, oxycodone, tramadol, fentanyl, and codeine. Benzodiazepines like alprazolam, diazepam, midazolam, lorazepam, clonazepam, flurazepam, temazepam, clorazepate, and chlordiazepoxide. Other insomnia medications like daridorexant (Quviviq).Barbiturates like amobarbital, butalbital, pentobarbital, phenobarbital, and secobarbital.Apalutamide and enzalutamide (medicines used to treat certain types of prostate cancer).Buprenorphine and naloxone (medications used to treat opioid addiction).Sodium oxybate (Xyrem), a medicine used to treat narcolepsy (excessive daytime sleepiness).Antidepressants like esketamine (Spravato nasal spray).Anticonvulsants like carbamazepine, phenytoin, fosphenytoin, primidone, gabapentin, and pregabalin.Parkinson’s medications like entacapone, opicapone, and tolcapone.Cystic fibrosis medications like ivacaftor and lumacaftor.Cancer drugs like imatinib.Antibiotics like amoxicillin, clarithromycin, and rifampin. Supplements like melatonin, valerian root, and St. John’s Wort.The above list is not a complete list of zolpidem drug interactions. Additionally, Ambien (zolpidem tartrate) can also have a drug interaction with alcohol and cannabis, leading to excessive drowsiness, next-day psychomotor impairment (slowed movements), and impaired driving. Give your doctor and pharmacist a complete list of your medications to lower your risk of zolpidem drug interactions and adverse reactions.References:https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/019908s027lbl.pdfhttps://medlineplus.gov/druginfo/meds/a693025.htmlhttps://www.pdr.net/drug-summary/Ambien-zolpidem-tartrate-2515.8323
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