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Author: Admin | 2025-04-28
Are more likely to occur if you take a higher dose. They’re also more likely if you take steroids long-term. It is a best practice to take the lowest dose you need for the shortest time. Side effects may include:Edema (swelling caused by fluid build-up)Hypertension (high blood pressure)High blood sugar levelsStomach painInsomnia (trouble sleeping)Mood changes HeadacheAcneWeight gain If taken long-term, over months to years, prednisone or prednisolone can potentially cause more severe side effects. If you’re experiencing any of the following side effects, inform your healthcare provider immediately:Eye problems (like glaucoma or cataracts)Osteoporosis (weaker bones)Infection, likely due to the drugs' suppression of your immune systemSevere stomach problems, including stomach ulcers or gastritis Adrenal gland problems, such as excessive tiredness or muscle weakness Interactions For Prednisolone and Prednisone Prednisolone and prednisone have very similar drug interactions. Some of these include:Jantoven (warfarin) is a blood thinner. When taken with steroids, blood can become too thin or not thin enough. In this case, specific labs, such as international normalized ratio (INR), should be monitored more closely.Non-steroidal anti-inflammatory drugs (NSAIDs) such as Motrin (ibuprofen) or meloxicam, can also cause bleeding issues when taken with steroids.Diabetes medications such as Glucophage (metformin) or glyburide that lower blood sugar may need to be increased. Steroids can cause an increase in blood sugar levels.Diuretics, or “water pills,” such as Lasix (furosemide) and Microzide (hydrochlorothiazide), may decrease your potassium level, which steroids can do as well. Your potassium level should be monitored closely for hypokalemia (low potassium levels in the body).Live vaccines, like the measles, mumps, and rubella (MMR) vaccine, may not work as well in people taking steroids. It’s best to wait to receive these vaccines until after steroids are discontinued. If you’ve been prescribed prednisolone or prednisone, ensure your healthcare provider and pharmacist know about all the medications and supplements you take, as some adjustments may need to be made. Summary Prednisone and prednisolone are corticosteroid drugs that mimic the action of the hormone cortisol, produced by your adrenal glands. They are very similar, although prednisone gets converted by your liver into prednisolone after you swallow it. The drugs have anti-inflammatory and immunosuppressive effects, which help treat many autoimmune diseases. The list of possible side effects is quite long, so using the lowest dose possible for the shortest amount of time is ideal.Frequently Asked Questions Prednisolone may be a preferred option if you have moderate to severe liver disease. This is because your liver is required to convert prednisone into its working form, prednisolone. There is no reason to take prednisolone and prednisone together, as prednisone gets converted to prednisolone in the body. Additionally, taking two steroids together can increase the likelihood of side effects generally caused
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