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Author: Admin | 2025-04-28
Benadryl is an over-the-counter (OTC) medication used for treating certain conditions, including allergies. Benadryl can interact with other medications and particular supplements.Benadryl (the branded form of diphenhydramine) is an antihistamine medication that people use to treat seasonal allergies, the common cold, and other allergic reactions that can cause itchiness and irritation. Benadryl can interact with several medications and supplements, such as antidepressants and melatonin. When a medication interacts with another drug or supplement, people can develop undesired side effects. Interaction can also reduce the efficacy of certain medications, such as antidepressants, or change the way they act on the body, potentially causing the opposite intended drug effect.1. AlcoholLauren Lee/Stocksy UnitedIf you are taking diphenhydramine (Benadryl), you should not drink any alcohol. This is because alcohol and Benadryl may interact and make you feel drowsier than usual. Consuming alcohol while taking Benadryl may increase the risk of developing side effects, such as:dizzinessconfusionreduced breathing ratemovement difficultiesIf you regularly take Benadryl, it is best to contact a doctor to find out whether it’s safe for you to drink alcohol and when you can consume it without having a higher risk of side effects.100% online careTreatment plans in 15 minutes or less for 40+ conditions.Start consult now2. Other antihistaminesBenadryl is a type of first-generation (H1) antihistamine. This means that alongside blocking histamine in your body, it can also pass the blood-brain barrier and enter your brain.You should never take Benadryl alongside other H1 antihistamine drugs. Taking different types of antihistamines at the same time can increase the risk of developing the drugs’ side effects or experiencing an overdose.People should avoid using Benadryl together with one of the following antihistamine medications unless directed to by a healthcare professional:cetirizine (Zyrtec)hydroxyzine (Vistaril)loratadine (Claritin)meclizine (Antivert)promethazine (Promethegan)If the benefit outweighs the risk, it may be possible to combine these medications, but only a healthcare professional will determine that.If you need help covering the cost of medications, the free Optum Perks Discount Card could help you save up to 80% on prescription drugs. Follow the links on drug names for savings on that medication, or search for a specific drug
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