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Author: Admin | 2025-04-28
Hallmark of erythromycin ototoxicity. It might also account for some reversibly to the hearing loss. Azithromycin, is a macrolide. Nevertheless, there are occasional reports of ototoxicity, when there have been prolonged and high levels. The high levels generally require intravenous dosing. Other types of antibiotics. Clindamycin has not been reported to cause ototoxicity, by itself, and is probably safe. Chloramphenicol has been sporadically reported to be ototoxic systemically. Metronidizole (Flagyl) has been reported on several occasions to be ototoxic (Blake and Butt 1984; Hibberd, Nicoll et al. 1984; Hibberd, Nicoll et al. 1984; Lawford and Sorrell 1994; Iqbal, Murthy et al. 1999; Riggs et al, 1990). Metronidizole toxicity fortunately appears to be rare and documented only by sporadic case reports.References re Metronidizole: Blake, P. and W. E. Butt (1984). "Ototoxicity of metronidazole." N Z Med J 97(753): 241. Hibberd, A. D., R. J. Nicoll, et al. (1984). "Deafness is an adverse reaction to the prophylactic use of metronidazole." N Z Med J 97(750): 128. Hibberd, A. D., R. J. Nicoll, et al. (1984). "Ototoxicity of metronidazole." N Z Med J 97(754): 275. Iqbal, S. M., J. G. Murthy, et al. (1999). "Metronidazole ototoxicity--report of two cases." J Laryngol Otol 113(4): 355-7. Lawford, R. and T. C. Sorrell (1994). "Amebic abscess of the spleen complicated by metronidazole-induced neurotoxicity: case report." Clin Infect Dis 19(2): 346-8.References r.e. macrolides: Bizjak, E. D., M. T. Haug, 3rd, R. J. Schilz, et al. (1999). "Intravenous azithromycin-induced ototoxicity." Pharmacotherapy19(2): 245-8. Etminan M, Westerberg BD, Kozak FK, Guo MY, Carleton BC. Risk of sensorineural hearing loss with macrolide antibiotics: A nested case-control study.Laryngoscope. 2016 Aug 6. doi: 10.1002/lary.26190. [Epub ahead of print] . Ikeda AK, Prince AA, Chen JX, Lieu JEC, Shin JJ. [Epub ahead of print] Macrolide-associated sensorineural hearing loss: A systemic review. Laryngoscope. 2017 Aug 3. doi: 10.1002/lary.26799. McGhan LJ and Merchant SN (2003). "Erythromycin ototoxicity." Otol Neurotol 24(4): 701-2. Mamikoglu, B. and O. Mamikoglu (2001). "Irreversible sensorineural hearing loss as a result of azithromycin ototoxicity. A case report." Ann Otol Rhinol Laryngol110(1): 102. Ress, B. D. and E. M. Gross (2000). "Irreversible sensorineural hearing
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