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Author: Admin | 2025-04-28
Of cancellous bone in the spine, osteoporotic changes are generally most conspicuous there. In vertebral body fractures caused by osteoporosis, the vertebra is deformed, with anterior wedging and collapse. If the vertebral body is not fractured, there is a general outline of both endplates, with a virtual absence of cancellous bone. Although senile osteoporosis tends to feature reduced trabecular thickness, postmenopausal osteoporosis exhibits disrupted connections between trabeculae. The loss of trabecular connectivity, which is attended by diminished biomechanical strength and ultimately provokes fracture, is due to perforation of trabeculae by resorbing osteoclasts in remodeling sites. Vertebral body compression fractures often occur after trivial trauma or may even follow lifting a heavy object. Estrogen therapy is an effective yet controversial means of preventing postmenopausal osteoporosis. Because hormone treatment carries with it increased risks of breast and endometrial cancers, other bone-specific antiosteoporotic drugs have been developed. All successful antiosteoporotic agents thus far developed block or slow the rate of bone resorption but do not stimulate bone formation. Thus, the drugs may prevent disease progression but cannot cure a patient who already has osteoporosis. Dietary calcium supplementation in elderly patients reduces the risk of osteoporotic fractures by half. Endocrine conditions: the most common form of secondary osteoporosis is iatrogenic and results from corticosteroid administration. Bone loss may also result from an excess of endogenous glucocorticoids, as in Cushing disease (see Chapter 27). Estrogen is a key hormone for maintaining bone mass, and its deficiency is the major cause of age-related bone loss in both sexes; estrogen deficiency or a low level of bioavailable estrogen decreases bone mass in elderly males.Buy 20 mg female cialis with amex. Dr. John Kim Obstetrics & Gynecology / Women's Health.
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