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Author: Admin | 2025-04-28
To gabapentin?Based on what we know, it makes more sense to use CBD to supplement gabapentin, rather than completely replace it.From a strength and efficacy standpoint, gabapentin will bring more intense relief than CBD will. It’s a medically-proven, FDA-approved painkiller. On the other hand, while CBD has shown promise, more studies are needed to confirm its efficacy for people with nerve pain.CBD is, however, more versatile than gabapentin. While gabapentin only reduces pain, CBD promotes both mental and physical health. CBD functions in a fundamentally different way than gabapentin does — neither is necessarily more effective. Instead, they can each play a role in supporting your health as you navigate nerve pain.Related: CBG for Nerve PainCBD Oil vs. Gabapentin for Nerve Pain: Frequently Asked QuestionsHere are some questions our customers frequently ask us about CBD oil vs. gabapentin for nerve pain. Does CBD take away nerve pain?Research suggests CBD may promote physical comfort and relaxation, and it’s commonly used for nerve pain-related conditions, like sciatica. However, more research is needed before we know whether or not CBD can take away nerve pain. What’s a natural alternative to gabapentin?Natural alternatives to gabapentin include CBD, cayenne, vitamin B12, zinc, and exercise. Can you mix gabapentin and CBD?Yes, you can safely mix gabapentin and CBD. CBD won’t cause a drug interaction with gabapentin, because gabapentin isn’t metabolized by the liver. Is CBD better than gabapentin for nerve pain?Preliminary research suggests CBD has therapeutic potential for nerve pain, and studies have indicated that CBD may reduce the amount of gabapentin patients need to take. However, more research on CBD is needed before we know if it can reliably reduce nerve pain, and no research directly comparing CBD and gabapentin has been done. Sources[1] Wiffen, Philip J et al. “Gabapentin for chronic neuropathic pain in adults.” The Cochrane database of systematic reviews vol. 6,6 CD007938. 9 Jun. 2017, doi:10.1002/14651858.CD007938.pub4[2] Abraham, Antony D et al. “Orally consumed cannabinoids provide long-lasting relief of allodynia in a mouse model of chronic neuropathic pain.” Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 45,7 (2020): 1105-1114. doi:10.1038/s41386-019-0585-3[3] Hjorthøj, Carsten et al. “Cannabis-based medicines and medical cannabis for patients with neuropathic pain and other pain disorders: Nationwide register-based pharmacoepidemiologic comparison with propensity score matched controls.” European journal of pain (London, England) vol. 26,2 (2022): 480-491. doi:10.1002/ejp.1874[4] Haney, Margaret. “Cannabis Use and the Endocannabinoid System: A Clinical Perspective.” The American journal of psychiatry vol. 179,1 (2022): 21-25. doi:10.1176/appi.ajp.2021.21111138[5] Hua, Daniel Ying-Heng et al. “Effects of cannabidiol on anandamide levels in individuals with cannabis use disorder: findings from a randomised clinical trial for the treatment of cannabis use disorder.” Translational psychiatry vol. 13,1 131. 21 Apr. 2023, doi:10.1038/s41398-023-02410-9[6] De Gregorio, Danilo et al. “Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.” Pain vol. 160,1 (2019): 136-150. doi:10.1097/j.pain.0000000000001386
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