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Author: Admin | 2025-04-28
And the analgesic effects of acetaminophen last between three and four hours.About 70-80% of a dose of codeine is metabolized by the liver into several metabolites, some active and some inactive. One of these active metabolites is morphine. About 5-10% of codeine is metabolized into morphine by the hepatic enzyme, CYP2D6. Experts believe some of the analgesic properties of codeine are due to it being converted into morphine. Note that up to 10% of Caucasians, 6% of Mexican-Americans, and 5% of African-Americans are poor metabolizers at CYP2D6 and are unlikely to metabolize codeine into morphine. 30% of Ethiopians, 20% of Saudis, 10% of Portuguese and Greeks, and 4% of North Americans are ultra-rapid metabolizers at CYP 2D6 and may experience excessive side effects, such as extreme sleepiness, confusion, and shallow breathing, even with recommended dosages of Tylenol With Codeine. 7. Interactions Medicines that interact with Tylenol With Codeine may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Tylenol With Codeine. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Common medications that may interact with Tylenol With Codeine include:antibiotics, such as erythromycinantidepressants, such as tricyclic antidepressants (eg, amitriptyline), monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine), or SSRIs (eg, fluoxetine, sertraline)antifungal agents, such as itraconazole and ketoconazole anticonvulsants, such as carbamazepine, lamotrigine, phenytoin,
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