Levothyroxine and fatigue

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Author: Admin | 2025-04-28

Can bind to more thyroid hormones, including thyroxine (T4) and triiodothyronine (T3), reducing the number of free thyroid hormones available to the body’s cells. This effect can create a functional hypothyroid state, even if the thyroid gland produces normal levels of thyroid hormones. Levothyroxine and Estrogen For people taking thyroid medication, such as levothyroxine, higher estrogen levels can interfere with the medication’s effectiveness by binding to the thyroid hormones, potentially necessitating an adjustment in the medication dosage to maintain therapeutic levels. Transdermal Estrogen Impact On Thyroid Medication The impact of transdermal estrogen on thyroid function might be less pronounced than oral estrogen’s, as transdermal administration bypasses the liver’s first-pass metabolism, potentially leading to less SHBG production. When estrogen levels increase due to transdermal estrogen therapy, SHBG levels may also rise. This can lead to more thyroid hormones binding to SHBG, decreasing the availability of free thyroid hormones for the body’s cells. This effect could create a functional hypothyroid state or reduce the effectiveness of thyroid medication. Weight Gain, Mood Swings, and Fatigue: Are Thyroid Medication and Estrogen Imbalances to Blame? Thyroid disorders, such as hypothyroidism (underactive thyroid) and hyperthyroidism (overactive thyroid), can cause many symptoms that affect your daily life. An underactive thyroid can lead to weight gain, fatigue, and mood swings, while an overactive thyroid can result in weight loss, irritability, and anxiety. Thyroid medication, such as levothyroxine for hypothyroidism or anti-thyroid drugs for hyperthyroidism, helps regulate thyroid hormone levels, which can alleviate these symptoms. Estrogen Imbalances and Their Effects on Weight Gain, Mood Swings, and Fatigue Estrogen imbalances, either estrogen dominance or deficiency, can also contribute to weight gain, mood swings, and fatigue. Estrogen is vital in regulating metabolism, mood, and energy levels. An imbalance in estrogen levels can lead to fluid retention, increased appetite, and changes in

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