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Author: Admin | 2025-04-28
At increased risk for other congenital anomalies,with cardiovascular anomalies (pulmonary stenosis, atrial septal defect, and ventricular septal defect,)being the most common association.Laboratory TestsGeneralThe diagnosis of hypothyroidism is confirmed by measuring TSH levels using a sensitive assay(second generation assay sensitivity ≤0.1 mIU/L or third generation assay sensitivity ≤0.01 mIU/L) andmeasurement of free-T4.The adequacy of therapy is determined by periodic assessment of appropriate laboratory tests andclinical evaluation. The choice of laboratory tests depends on various factors including the etiology ofthe underlying thyroid disease, the presence of concomitant medical conditions, including pregnancy,and the use of concomitant medications (see PRECAUTIONS, DRUG INTERACTIONS and Drug-Laboratory Test Interactions). Persistent clinical and laboratory evidence of hypothyroidism despitean apparent adequate replacement dose of LEVOXYL may be evidence of inadequate absorption, poorcompliance, drug interactions, or decreased T4 potency of the drug product.AdultsIn adult patients with primary (thyroidal) hypothyroidism, serum TSH levels (using a sensitive assay)alone may be used to monitor therapy. The frequency of TSH monitoring during levothyroxine dosetitration depends on the clinical situation but it is generally recommended at 6 - 8 week intervals untilnormalization. For patients who have recently initiated levothyroxine therapy and whose serum TSH hasnormalized or in patients who have had their dosage or brand of levothyroxine changed, the serum TSHconcentration should be measured after 8 - 12 weeks. When the optimum replacement dose has beenattained, clinical (physical examination) and biochemical monitoring may be performed every 6 - 12months, depending on the clinical situation, and whenever there is a change in the patient's status. It
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