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Author: Admin | 2025-04-28
Spinningstomach discomfort or upsetswelling For healthcare professionalsApplies to lisinopril: oral solution, oral tablet.Cardiovascular adverse eventsVery common (10% or more): Hypotension (11%)Common (1% to 10%): Chest pain, angina pectoris, orthostatic hypotension, palpitationsUncommon (0.1% to 1%): Angioneurotic edema, myocardial infarction or cerebrovascular accident, palpitations, tachycardia, Raynaud's phenomenon[Ref]Hypotension is most likely in patients who are sodium and intravascular volume depleted. In large studies, patients have reported "heart pounding" and chest pain, although the relationship to lisinopril is questionable.[Ref]RenalCommon (1% to 10%): Creatinine increased (10%)Very rare (less than 0.01%): Renal insufficiency[Ref]Nervous systemVery common (10% or more): Dizziness (19%)Common (1% to 10%): Headache, syncopeUncommon (0.1% to 1%): Paresthesias[Ref]RespiratoryCommon (1% to 10%): Creatinine increased (10%)Uncommon (0.1% to 1%): RhinitisVery rare (less than 0.01%): Bronchospasm, sinusitis, allergic alveolitis/eosinophilic pneumonia[Ref]A study has revealed a significantly higher incidence of discontinuation of angiotensin converting enzyme inhibitor therapy due to cough among black patients compared with nonblack patients (9.6% vs. 2.4%).[Ref]MetabolicCommon (1% to 10%): HyperkalemiaFrequency not reported: Gout, hypoglycemia in diabetic patients receiving ACE inhibitors when concurrently treated with oral antidiabetic agents or insulin[Ref]GastrointestinalCommon (1% to 10%): Diarrhea, nausea, vomitingFrequency not reported: Pancreatitis, constipation, flatulence, dry mouth, taste disturbance[Ref]HypersensitivityUncommon (0.1% to 1%): Angioedema[Ref]DermatologicUncommon (0.1% to 1%): Rash, pruritus, erythemaRare (0.01% to 0.1%): Alopecia, urticaria, psoriasis, hypersensitivity/angioedema, angioneurotic edema of the face, extremities, lips, tongue, glottis, and/or larynx Very rare (less than 0.01%): Sweating, skin lesions, skin infections, pemphigus, toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, cutaneous pseudolymphomaFrequency not reported: Photosensitivity, flushing, diaphoresis[Ref]HematologicVery rare (less than 0.01%): Bone marrow depression, hemolytic anemia, leukopenia/neutropenia, thrombocytopenia, decreases in hemoglobin, decreases in hematocrit[Ref]PsychiatricRare (0.01% to 0.1%): Memory impairment, confusion, somnolence, irritability, nervousness, hallucinationsVery rare (less than 0.01%): ManiaHepaticCommon (1% to 10%): Creatinine increasedVery rare (less than 0.01%): Cholestatic jaundice that progresses to fulminant hepatic necrosis and sometimes death (discontinue of therapy if jaundice or markedly elevated hepatic serum enzymes develop)EndocrineVery rare (less than 0.01%): Diabetes, syndrome of inappropriate antidiuretic hormone secretion (SIADH)OtherCommon (1% to 10%): CoughFrequency not reported: Fatigue, asthenia, orthostatic effects, tinnitus, olfactory disturbanceGenitourinaryUncommon (0.1% to 1%): ImpotenceRare (less than 0.1%): GynecomastiaFrequency not reported: ProteinuriaReferences1. (2002) "Product Information. Prinivil (lisinopril)." Merck & Co., Inc2.
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