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Author: Admin | 2025-04-28
Primack explains that while on orlistat, “Your body doesn’t know the difference between passing gas and an oily diarrhea. So you would soil yourself and have to go home and change your clothes.”(Related: Protein for Weight Loss: How Much Protein Should You Eat?)More FDA-approved GLP-1 agonists entered the market during the 2010s, including the following:Victoza® injections for diabetes (2010)Saxenda® injections for obesity (2014)Ozempic injections for diabetes (2017)Rybelsus® tablets for diabetes (2019)The FDA in 2014 approved Contrave® tablets as a weight loss treatment featuring naltrexone (an opioid antagonist) and bupropion (an antidepressant) as active ingredients.Next-generation GLP-1s entered the market in the 2020s, including the following injectable medications:Wegovy for weight loss (2021)Mounjaro® for diabetes (2022)Zepbound® for weight loss (2023)The active ingredient in Wegovy (semaglutide) is the same active ingredient in Ozempic and Rybelsus. The difference is that weekly Ozempic injections and daily Rybelsus tablets are not approved for weight management. Even so, physicians may prescribe Ozempic and Rybelsus off-label for weight loss.(Related: Wegovy vs. Ozempic for Weight Loss)In recent years, other weight loss treatment options that include a combination of medications have entered the market. In 2023, Hims & Hers launched a weight management program that includes a personalized combination of medications such as bupropion, metformin, topiramate, naltrexone, and vitamin B.“Different medicines work on different parts of the brain,” says Dr. Primack.Doctors sometimes prescribe off-label medications to help support weight loss goals. When you take an off-label drug, you're taking it for something other than what it was FDA-approved to treat. For example, metformin is FDA-approved for the treatment of type 2 diabetes, but it can be prescribed off-label to treat obesity. And pairing the medication with nutrition plans and behavioral programs, like those offered in the Hims & Hers app, allows people to address weight loss more holistically. The complete history of weight loss drugs is one of research and development. “We’ve gone from medicines that had lots of side effects and low efficacy,” says Dr. Primack, to those that have “less side effects and high efficacy.”People with obesity now have multiple treatment options available to them. And changing societal perceptions of weight loss drugs have encouraged more people to make use of these weight loss tools. Future weight loss drugs may continue to push the envelope for treating obesity with innovative and exciting solutions.25 SourcesHaslam D. (2016). Weight management in obesity – past and present. International Journal of Clinical Practice,
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