Methadone mechanism of action

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Author: Admin | 2025-04-28

What is methadone used for?Methadone is commonly used for the following conditions. Management of severe, chronic painDetoxification from opioids in people with an opioid use disorderMaintenance of recovery in people with an opioid use disorder Methadone may also be used for other conditions as determined by your healthcare provider.How does methadone work (mechanism of action)?Methadone works by activating opioid receptors. This produces an effect similar to other prescription opioids like morphine. Activating opioid receptors reduces the feeling of pain in the body. How is methadone supplied (dosage forms)?Brands and other namesDisketsDolophineMethadoseDosage forms and strengths10 mg/mL oral concentrate5 mg/5 mL, 10 mg/5 mL oral solution5 mg, 10 mg oral tablets40 mg dispersible tablets for oral suspensionMethadone is also available in injectable forms.How should I store methadone?Methadone should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Side Effects What are the most common side effects of methadone?The most common side effects of methadone are listed below. Tell your healthcare provider if you have any of these side effects that bother you.Lightheadedness or dizzinessSleepiness or tirednessNausea or vomitingSweatingConstipationHeadacheStomach painThere may be other side effects of methadone that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.What are the serious side effects of methadone?While less common, the most serious side effects of methadone are described below, along with what to do if they happen.Severe Allergic Reactions. Methadone may cause allergic reactions, which can be serious. Stop taking methadone and get help right away if you have any of the following symptoms of a serious allergic reaction.Breathing problems or wheezingRacing heartFever or general ill feelingSwollen lymph nodesSwelling of the face, lips, mouth, tongue, or throatTrouble swallowing or throat tightnessItching, skin rash, or pale red bumps on the skin called hivesNausea or vomitingDizziness, feeling lightheaded, or faintingStomach crampsJoint painIncreased Pain and Pain Sensitivity. Methadone may cause allodynia, which is when you have pain from something that normally does not cause pain such as brushing your hair. Methadone may also cause opioid induced hyperalgesia, which is when something that causes pain can make you feel more intense pain. Contact your healthcare provider right away if you have pain from things that did not cause pain before or an increase in pain intensity.

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