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Author: Admin | 2025-04-28
Methadone Chemical Nomenclature Common names Methadone, Dolophine, Methadose Systematic name (RS)-6-(dimethylamino)-4,4-diphenylheptan-3-one Class Membership Psychoactive class Opioid Chemical class Diphenylpropylamine Routes of Administration WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Bioavailability 40-99% Threshold 1 mg Light 3 - 5 mg Common 5 - 15 mg Strong 15 - 30 mg Heavy 30 mg + Duration Total 10 - 19 hours Onset 20 - 90 minutes Come up 2 - 4 hours Peak 4 - 6 hours Offset 4 - 6 hours After effects 1 - 24 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy. Interactions MAOIsNitrousPCPStimulants SNRIsAlcoholBenzodiazepinesDXMGHBGBLKetamineMXETramadolGrapefruitMAOIsSerotonin releasersSSRIs5-HTPMethadone (sold under trade names such as Dolophine and Methadose) is a synthetic opioid analgesic used for the treatment of moderate to severe pain and for the treatment of opioid addiction. It is commonly used to treat and manage the symptoms of opioid addiction. The subjective effects are similar to those of other synthetic opioids such as fentanyl, however, most users note a significantly stronger euphoria. Like dextropropoxyphene, the use of methadone is associated with cardiac arrhythmia, however it is more common with dextropropoxyphene than it is with methadone.ChemistryMethadone is an opioid of the diphenylpropylamine class, featuring two phenyl rings attached to carbon R4 of the main 2-oxo-6-dimethylaminoheptane chain. It exists as a racemic mixture of both dextromethadone and levomethadone. It is also similar in structure to tapentadol and dextropropoxyphene.Methadone and its major metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), are often measured in urine as part of a drug abuse testing program, in plasma or serum to confirm a diagnosis of poisoning in hospitalized victims, or in whole
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