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Author: Admin | 2025-04-28
Associated with feeling satisfied after a meal.Nearly a decade after the withdrawal of fenfluramine (part of Fen-Phen) and dexfenfluramine from the market, and with an expansion of knowledge in the area of obesity, a new second generation of weight loss medications was developed. These target the central regions of your brain, as well as your digestive tract. Examples of these new medications include:Bupropion-naltrexone (Contrave®):This combines two drugs. Bupropion is an anti-depressant. Naltrexone is often used to treat opioid addiction. Together, they decrease hunger and reduce cravings.Phentermine-topiramate (Qsymia®): This medication also combines two drugs: phentermine is a stimulant and topiramate is an anti-seizure medication. The drug lessens hunger and increases feelings of fullness.Liraglutide (Saxenda®).Lorcaserin (Belviq®).New weight loss drugsOver the last decade, drug development has turned its attention to gut hormones like glucagon-like peptide‐1 (GLP-1), amylin, glucose-dependent insulinotropic peptide (GIP) and (peptide tyrosine-tyrosine) PYY, which are intricately involved in appetite and weight regulation. Many of them are used to treat both obesity and Type 2 diabetes.Surprisingly, recent clinical trials have demonstrated superior weight loss results and, together with a safer side effect profile, have made this third generation of anti-obesity medications very attractive compared with the older drugs. These therapies mimic the hormones that your intestines produce when you eat. The hormones tell your pancreas to release insulin. GLP-1 also:Increases feelings of fullness.Keeps food in your stomach longer.Reduces blood sugar levels.The newest weight loss drug approved by the U.S. Food and Drug Administration is semaglutide (Wegovy™), which is just the higher dose (2.4 milligrams) of the same medication, Ozempic®, which was approved four years earlier for Type 2 diabetes. Although this class of GLP-1 receptor agonist medications has existed since 2005 with exenatide (Byetta®) and liraglutide (Victoza, Saxenda), and used to treat Type 2 diabetes, longer-acting once-weekly GLP-1 medications like dulaglutide (Trulicity®) have appeared to be more effective in treating obesity and lowering blood sugar.Are the new weight loss drugs effective?In addition to being effective diabetes medications, GLP-1 drugs are useful for obesity. For instance, in a study of 2.4 mg of semaglutide, adults with obesity who took the drug lost an
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