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Author: Admin | 2025-04-28
Is discontinued, the former user’s physiology remains in an omeprazole-adapted state such that, for a week or two following discontinuation, gastric acid production is greater than usual (homeostatic baseline) – possibly due to the fact that the body upregulated its endogenous production of gastric acid to counterbalance the acid-lowering effect of omeprazole. Thus, when the medication is discontinued, the increased gastric acid production might [transiently] linger and cause unwanted “withdrawal symptoms.”What about the neuropsychiatric manifestations of withdrawal? For those reporting neuropsychiatric symptoms after discontinuing omeprazole, it’s possible that transient rebound acid hypersecretion might alter gut bacteria and cause inflammation. Altered gut bacteria and/or proinflammatory cytokines in the peripheral could undergo central uptake to alter neurotransmitter concentrations and provoke anxiety, depression, headaches, etc.Source: https://www.ncbi.nlm.nih.gov/pubmed/9930386Variables that influence the severity of omeprazole withdrawalIncluded below is a list of variables that might influence the severity of omeprazole withdrawal symptoms. Variables that could influence withdrawal symptom severity include: duration of omeprazole treatment; omeprazole dosage; and rate of discontinuation. A person’s lifestyle (diet, exercise habits, stress) and/or genetics might also impact withdrawal severity.Duration of omeprazole treatmentThe total amount of time over which you’ve been using omeprazole might influence the difficulty of your withdrawal. Most research and anecdotal reports suggest that extremely brief or short-term omeprazole treatment (e.g. several days) is unlikely to cause discontinuation symptoms.If withdrawal symptoms occur following short-term omeprazole use, they are unlikely to be severe and/or protracted. Comparatively, it is thought that moderate-term (weeks/months) and long-term omeprazole administration increase one’s risk of rebound acid hypersecretion – and severe withdrawal symptoms.According to survey data moderate-term proton-pump inhibitor use induces withdrawal symptoms of mild-to-moderate severity (in a subset of former users). Nevertheless, because omeprazole and proton-pump inhibitors don’t appear to induce clinically significant tolerance (even with long-term use), there may not be noticeable differences in withdrawal severity between moderate-term and long-term users.Omeprazole dosage (during treatment)The dosage of omeprazole utilized during treatment might also influence the severity of discontinuation symptoms. Specifically, it is thought that high-dose omeprazole users might be at greater risk of experiencing severe withdrawals in comparison to persons who used omeprazole at low doses.Firstly, it is necessary to underscore the fact that individuals who used omeprazole at high doses probably had more substantial acid reflux at baseline (before treatment) – than persons who used lower-dose omeprazole. This considered, it’s reasonable to speculate that, when a high-dose user discontinues treatment – severe acid reflux
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