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Author: Admin | 2025-04-28
And faeces 10,11,12. In humans, less than 10% of the dose is excreted unchanged in the urine 10,11,12. The major urinary metabolites are glucuronide conjugates (45%), sulphate conjugates (20%) and hydroxylation products (10%) 10,11,12. The primary metabolic pathway is subsequently hydroxylation on the indole ring followed by subsequent glucuronide or sulfate conjugation 10,11,12. Although some nonconjugated metabolites have pharmacologic activity, these are not found in plasma at concentrations likely to significantly contribute to the biological activity of ondansetron 10,11,12.Hover over products below to view reaction partnersRoute of eliminationFollowing oral or IV administration, ondansetron is extensively metabolised and excreted in the urine and faeces 11,12.Half-lifeThe half-life of ondansetron after either an 8 mg oral dose or intravenous dose was approximately 3-4 hours and could be extended to 6-8 hours in the elderly 11,12. ClearanceThe clearance values determined for ondansetron in various patient age groups were recorded as approximately 0.38 L/h/kg in normal adult volunteers aged 19-40 yrs, 0.32 L/h/kg in normal adult volunteers aged 61-74 yrs, 0.26 L/h/kg in normal adult volunteers aged >=75 yrs Label.Adverse EffectsImprove decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.ToxicityAt present, there is little information concerning overdosage with ondansetron 10,11,12. Nevertheless, there have been certain cases of somewhat idiosyncratic adverse effects associated with particular dosages of ondansetron used 10,11,12.“Sudden blindness” (amaurosis) of 2 to 3 minutes duration plus severe constipation occurred in one patient that was administered 72 mg of ondansetron intravenously as a single dose 10,11,12. Hypotension (and faintness) occurred in another patient that took 48 mg of oral ondansetron 10,11,12. Following infusion of 32 mg over only a 4-minute period, a vasovagal episode with transient second-degree heart block was observed 10,11,12. Neuromuscular abnormalities, autonomic instability, somnolence, and a brief generalized tonic-clonic seizure (which resolved after a dose of benzodiazepine) were observed in a 12-month-old infant who ingested seven or eight 8-mg ondansetron tablets (approximately forty times the recommended 0.1-0.15 mg/kg dose
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