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Author: Admin | 2025-04-28
For a pediatric patient) 10,11,12. In all instances, however, the events resolved completely 10,11,12.The safety of ondansetron for use in human pregnancy has not been established 11,12. Ondansetron is not teratogenic in animals 11,12. However, as animal studies are not always predictive of human response, the use of ondansetron in pregnancy is not recommended 11,12.Ondansetron is excreted in the milk of lactating rats 11,12. It is not known if it is excreted in human milk, however, nursing is not recommended during treatment with ondansetron 11,12.Insufficient information is available to provide dosage recommendations for children 3 years of age or younger 11,12. PathwaysNot AvailablePharmacogenomic Effects/ADRs Interacting Gene/EnzymeAllele nameGenotype(s)Defining Change(s)Type(s)DescriptionDetailsCytochrome P450 2D6CYP2D6*1xN,Not AvailableGene duplication.Effect Directly StudiedPatients with this genotype in CYP2D6 are ultrarapid metabolizers with an increased risk of poor therapeutic response and vomiting when treated with ondansteron.DetailsCytochrome P450 2D6CYP2D6*2xNNot AvailableGene duplication.Effect Directly StudiedPatients with this genotype in CYP2D6 are ultrarapid metabolizers with an increased risk of poor therapeutic response and vomiting when treated with ondansteron.DetailsCytochrome P450 2D6CYP2D6*1XNNot AvailableNormal allele duplicated.ADR InferredUltra-rapid drug metabolizer. Risk of toxicity, alternative drug recommended.DetailsCytochrome P450 2D6CYP2D6*2XNNot Available2850C>T / 4180G>C … show all ADR InferredUltra-rapid drug metabolizer. Risk of toxicity, alternative drug recommended.DetailsCytochrome P450 2D6CYP2D6*1XNNot AvailableNormal allele duplicated.Effect InferredPoor responseDetailsDrug Interactions This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist. ApprovedVet approvedNutraceuticalIllicitWithdrawnInvestigationalExperimentalAll DrugsDrugInteractionIntegrate drug-drug interactions in your software1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when Ondansetron is combined with 1,2-Benzodiazepine.AbametapirThe serum concentration of Ondansetron can be increased when it is combined with Abametapir.AbataceptThe metabolism of Ondansetron can be increased when combined with Abatacept.AbirateroneThe serum concentration of Ondansetron can be increased when it is combined with Abiraterone.AbrocitinibThe metabolism of Abrocitinib can be decreased when combined with Ondansetron.Food InteractionsTake with or without food. The absorption is unaffected by food.Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.Product
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