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Author: Admin | 2025-04-28
If salicylic acid is like gentle sandpaper for your skin, isotretinoin (commonly referred to by the now-defunct brand name Accutane) is paint stripper: It gets the job done when nothing else will, and it comes with plenty of safety warnings. "In the '80s, it didn't have the level of regulation it has today," says Joshua Zeichner, the director of cosmetic and clinical research in dermatology at Mount Sinai Hospital. "Then, as reports of depression and suicides became a popular media topic in the '90s and 2000s—and as lawyers on television began encouraging patients to sue their dermatologists for putting them on the drug—it developed a bad reputation." Over the last three decades, stricter regulatory policies have been put in place, and "while isotretinoin is a serious drug that requires close monitoring, it's an effective medication for severe acne." If you're confused, you're not alone. Here's how it breaks down.The Pros:Isotretinoin is an internal retinoid, which is a vitamin A derivative, and it's the only drug that addresses all four major acne-causing factors: It reduces skin oil production, improves cell turnover inside pores, decreases the naturally occurring P. acnes bacteria on the skin, and calms inflammation.It's hands-down the most effective way to improve severe cystic acne when no other treatments work.Once acne is gone, it's either gone for good or, if it comes back, it will most likely not be as severe.The Cons:It will probably cause severe dryness and irritation.It can cause birth defects. To go on isotretinoin, patients must enroll in the FDA's iPledge program, which requires women to be on two forms of birth control for a month before starting and a month after discontinuing their prescription.There have been suggested relationships between isotretinoin use and depression, anxiety, and inflammatory bowel disease. The American Academy of Dermatology's official position is that, based on current evidence, isotretinoin is still appropriate to use if patients are aware of the risks.The best skin-care products:
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