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Author: Admin | 2025-04-28
In patients with renal failure. Use: Labeled IndicationsChronic drooling (Cuvposa only): To reduce chronic, severe drooling in pediatric patients 3 to 16 years with neurologic conditions (eg, cerebral palsy) associated with problem droolingReduction of secretions (injection only): To reduce salivary, tracheobronchial, and pharyngeal secretions and to reduce the volume and acidity of gastric secretions during induction of anesthesia and intubationReversal of bradycardia, vagal reflexes (injection only): To block cardiac vagal inhibitory reflexes during induction of anesthesia and intubation; intraoperatively to counteract surgically or drug-induced or vagal reflexes associated arrhythmiasReversal of muscarinic effects of cholinergic agents (injection only): Protects against the peripheral muscarinic effects (eg, bradycardia, excessive secretions) of cholinergic agents (eg, neostigmine, pyridostigmine) given to reverse the neuromuscular blockade due to non-depolarizing muscle relaxants Use: Off LabelPrimary focal hyperhidrosiscyesRetrospective data from a limited number of patients suggests that systemic therapy with oral glycopyrrolate may be beneficial for treatment of primary focal hyperhidrosis Bajaj 2007, Lee 2012, Walling 2012. The Canadian Hyperhidrosis Advisory Committee guideline on treatment of primary focal hyperhidrosis recommends oral glycopyrrolate as an option for first-line therapy of craniofacial hyperhidrosis and as alternative therapy in severe cases of axillary, palmar, or plantar hyperhidrosis unresponsive to first- or second-line therapies Solish 2007. Additional data may be necessary to further define the role of glycopyrrolate in this condition. ContraindicationsHypersensitivity to glycopyrrolate or any component of the formulation; medical conditions that preclude use of anticholinergic medication (eg, severe ulcerative colitis, toxic megacolon complicating ulcerative colitis, paralytic ileus, obstructive disease of GI tract [eg, achalasia, pyloroduodenal stenosis], intestinal atony in elderly or debilitated patients, unstable cardiovascular status in acute hemorrhage, glaucoma, obstructive uropathy [eg, bladder neck obstruction due to prostatic hypertrophy], myasthenia gravis)Oral solution: Additional contraindication: Concomitant use of potassium chloride in a solid oral dosage form Dosage and AdministrationDosing: AdultPrimary focal
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