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Author: Admin | 2025-04-28
Was significant (p decrease in ADA activity of penile tissues in rats treated with SD and combination of BCP and SD when compared Fig. 1 Influence of β-caryophyllene, sildenafil and their combina-tion on acetylcholinesterase (AChE) of normal and paroxetine-induced sexual dysfunction in rats’ penile tissue. Bars represent mean ± standard deviation of five readings (n = 5). #p 0.05; ##pppp0.01; ***p0.001; different from PD. NCnormal control; SD sildenafil; PD paroxetine; BCP β-caryophyllene, BCP + SD combination of β-caryophyllene and sildenafilFig. 2 Influence of β-caryophyllene, sildenafil and their combina-tion on phosphodiesterase 5 (PDE-5’) of normal and paroxetine-induced sexual dysfunction in rats’ penile tissue. Bars represent mean ± standard deviation of five readings (n = 5). #p 0.05; ##pppp0.01; ***p0.001; different from PD. NCnormal control; SD sildenafil; PD paroxetine; BCP β-caryophyllene, BCP + SD combination of β-caryophyllene and sildenafil Toxicol Res.1 3with NC group. ADA activity was significantly (p higher in PD group as compared to NC group. Signifi-cant reduction in ADA activity of PD rats treated with BCP (20mg/kg) (p mg/kg) (p the combination of BCP (20mg/kg) and SD (20mg/kg) (p observed.Figure5 reveals the effect of SD, BCP and their com-bination on ACE activity in penile tissues of normal and paroxetine-induced rats. The activity of ACE was sig-nificantly (p 0.01) elevated in PD rat group when com-pared with NC group. Furthermore, PD rat groups treated with BC (10mg/kg) (p 0.05), BCP (20mg/kg) and SD (20mg/kg) and combination of BCP (20mg/kg) and SD (20mg/kg) had significantly (p 0.05) lower ACE activity in comparison to the PD group.Figure6 depicts a significant (p 0.01) increase in the level of lipid peroxidation (LPO) of PD rat group when compared with NC group. However, the administration of BCP (10 & 20mg/kg), SD (20mg/kg) and both BCP (20mg/kg) and SD (20mg/kg) in PD rats caused signifi-cant (p
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