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Author: Admin | 2025-04-28
Dispensed prescriptions of two 75 mg aspirin doses once a day) or 160 mg of aspirin during pregnancy. The reference group was women using 75 mg of aspirin. Data on aspirin dose were obtained from the first dispensed prescription in the pregnancy, as recorded in the Swedish Prescribed Drug Register (eTable 1 in Supplement 1). We included 2 primary outcomes to reflect effectiveness and safety, both determined a priori. For effectiveness, our primary outcome was a diagnosis of preeclampsia recorded in the maternal birth record at the time of hospital discharge. For safety, our main outcome was postpartum hemorrhage, defined as bleeding of more than 1000 ml within 24 hours of delivery. Secondary outcomes included gestational age at delivery with preeclampsia diagnosis (17), antepartum hemorrhage, intrapartum hemorrhage, postpartum hematoma, neonatal intracranial bleeding, and anemia at time of birth. The information on outcomes was obtained from the Medical Birth Register. For anemia, information was obtained from both the Medical Birth Register and the National Patient Register (eTable 1 in Supplement 1). We conducted stratified analyses by vaginal birth or cesarean delivery for the outcomes of postpartum hemorrhage, intrapartum hemorrhage, postpartum hematoma, neonatal intracranial bleeding, and anemia. We also performed sensitivity analyses for the primary outcomes of preeclampsia and postpartum hemorrhage in nulliparous women (women pregnant with their first child). An a priori statistical analysis plan was developed and agreed upon by all authors and is provided in the eAppendix in Supplement 1. Population characteristics were described by aspirin dose (75 mg or 150-160 mg) and summarized using mean (SD), median (IQR), and number (%) according to type and distribution of data. To investigate the association between aspirin dose (150-160 mg compared with 75 mg [reference group]) and outcomes, a doubly robust inverse probability–weighted regression adjustment (IPWRA) was employed using the teffects
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